Inhibition of Chlamydial Infectious Activity due to P2X7R-Dependent Phospholipase D Activation
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چکیده
منابع مشابه
Inhibition of chlamydial infectious activity due to P2X7R-dependent phospholipase D activation.
Chlamydia trachomatis survives within host cells by inhibiting fusion between Chlamydia vacuoles and lysosomes. We show here that treatment of infected macrophages with ATP leads to killing of chlamydiae through ligation of the purinergic receptor, P2X(7)R. Chlamydial killing required phospholipase D (PLD) activation, as PLD inhibition led to rescue of chlamydiae in ATP-treated macrophages. How...
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29. Brooks, G., Evans, A. T., Aitken, A. & Evans, F. J. (1987) Cancer Lett. 38,165-170 Evans, A. T., Brooks, G. & Evans, F. J. (1990) Cancer Lett. 49,2529 Evans, F. J., Kinghorn, A. D. & Schmidt, R. J. (1975) Acta Pharmacol. Toxicol. 37,250-256 Tapley, P. M. & Murray, A. W. (1985) Eur. J. Biochem. 151,419-423 Edwards, M. C., Williamson, E. M., Formakong, E., Brooks, G. & Evans, F. J. (1987) Bio...
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Increased cAMP by stimulation of adenylyl cyclase with forskolin or by beta-adrenoceptor activation with isoproterenol increased phospholipase D (PLD) activity in tracheal smooth muscle strips. PLD activity was measured by the accumulation of phosphatidylethanol. A linear increase in the concentration of phosphatidylethanol was observed over 20 min in muscle strips treated with either forskolin...
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ژورنال
عنوان ژورنال: Immunity
سال: 2003
ISSN: 1074-7613
DOI: 10.1016/s1074-7613(03)00235-8